A medical indication to perform a particular test or administer
a particular treatment may be a medical reason to perform that test or administer
that treatment. Stedman’s Medical Dictionary (2005) defines a medical
indication as “the basis or rationale for using a particular treatment or
diagnostic test,” and says that it “may be furnished by a knowledge of the
cause (causal indication), by the symptoms present (symptomatic indication), or
by the nature of the disease (specific indication).”1
A medical indication may also be a situation
or condition in which a particular test or treatment is advised or recommended,
based on the available scientific evidence. For example, according to the
Physicians’ Desk Reference (2015), the indications for prescription of an
albuterol inhaler include “Treatment or prevention of bronchospasm in patients
4 years of age and older with reversible obstructive airway disease,” and “Prevention
of exercise-induced bronchospasm in patients 4 years of age and older.”2
A medical indication may also be an
evidence-based justification for a particular test or treatment. The strength
of the indication may depend on the strength of the available scientific evidence for that indication.
Factors affecting the indication for
a particular test or treatment include not only the nature of the particular
disease process under consideration, but also the potential benefits and
efficacy of treatment, the age of the patient, the overall condition of
the patient, the personal desires and preferences of the patient, the potential
side-effects and burdens of treatment for the patient, the costs of treatment, the availability of
treatment, and the projected goals of treatment.
A medical non-indication for the
performance of a particular test or administration of a particular treatment is an absence or lack of indication to perform that test or administer that
treatment. Reasons that medical tests or treatments may not be
indicated include: the non-health-threatening nature of some medical conditions,
the lack of treatment efficacy with regard to some medical conditions, the potential
side-effects of some treatments, the potential financial burdens of some
treatments, and the personal desires of some patients not to undergo arduous
tests and treatment.
A medical contraindication to a
particular test or treatment is a medical reason not to perform that test or
treatment (because the test or treatment may be injurious or harmful to the
patient). A contraindication may be described as relative or absolute. A
relative contraindication to a test or treatment may sometimes be outweighed by
the potential benefits of that test or treatment if the potential benefits are
significant and the risk of harm is very low, but an absolute contraindication
to a test or treatment is never outweighed by the potential benefits of that
test or treatment (because of the severity and magnitude of the potential harms
that the test or treatment may cause to the patient)
What then is the relation between
medical indications and epistemic justifications? To say that a particular test
or treatment is medically indicated is to make an epistemic claim regarding the
appropriateness, correctness, and advisability of that test or treatment. If we
make such a claim, then we may have an epistemic duty to justify it by
thoroughly examining all the available evidence for and against it. In order to
be epistemically justified in saying that a particular test or treatment is
medically indicated, we must have sufficient epistemic grounds for saying so.
Let’s consider the following
propositions (where the letter “T” stands for a medical test or treatment) as a
method of investigating the role and function of medical indications as epistemic justifications:
1.
If T is medically indicated, then it is medically (and epistemically, and ethically) justified.
2. If T is medically indicated, then there are good medical reasons for it that sufficiently outweigh any possible or actual reasons against it.
3.
If T is medically indicated, then there is
sufficient scientific evidence in favor of it, and there is insufficient
scientific evidence against it.
4.
If T is medically indicated, then there is sufficient scientific evidence of its benefit, safety, and efficacy.
5.
The proposition P that a particular test or
treatment T is medically indicated is epistemically justified if there is
sufficient scientific evidence in favor of the truth of P.
The above propositions may all have their
corresponding negations. Thus, if
T is not medically indicated, then it is not medically (and not epistemically, and not ethically) justified, and so on.
To what extent may medical
indications differ from epistemic justifications? Medical indications may be
more than epistemic justifications, insofar as they may be not only epistemic,
but also ethical (and practical) in nature. They may be not only situations or conditions
in which particular tests or treatments are said to be appropriate or advisable,
but also parameters and guidelines for performing tests and prescribing treatments.
Medical indications may also differ
from epistemic justifications insofar as in some cases an argument can be made
that a test or treatment may be epistemically (and ethically) justified without
clearly being medically indicated (its justification may not be apparent at
first glance and may only be apparent on later examination). A test or
treatment that was not clearly indicated at first glance may turn out to have an
unanticipated beneficial effect. However, such a possibility may still not provide sufficient grounds for the argument that the performance of non-indicated tests or
treatments can in some cases be medically justified. The justifiability of a
medical test or treatment may in fact depend on the strength, clarity, and sufficiency of
the indications for that test or treatment. Tests or treatments that have weak, unclear, or insufficient indications may be medically (and epistemically, and ethically) compromised by their weak, unclear, or insufficient
justification.
Non-indication, or lack of
indication, for a test or treatment may in some cases be a contraindication to
that test or treatment, insofar as that test or treatment may pose unnecessary
risks to the patient and may expose the patient to unnecessary harms.
Non-indicated tests or treatments may also cause unnecessary financial expenses
for patients, for third-party payers, and for a whole healthcare system.
Medical indications may constitute
reasons to perform particular tests, procedures, or treatments, based on our
knowledge of the potential benefits, safety, and efficacy of those tests,
procedures, and treatments, and based on our knowledge of the natural history of
the disease processes under consideration. Medical indications may also affirm
the usefulness, appropriateness, and rationality of particular tests,
procedures, and treatments within the context of particular medical illnesses,
disease processes, and conditions.
FOOTNOTES
1Stedman’s
Medical Dictionary for the Health Professions and Nursing, Fifth Edition,
edited by Thomas Lathrop Stedman (Baltimore: Lippincott Williams & Wilkins,
2005), p. 735.
2PDR, LLC “Full Prescribing Information, ProAir
HFA (albuterol sulfate),” 2015, at http://www.pdr.net/full-prescribing-information/proair-hfa?druglabelid=569.